What is a standard full anticoagulation dose of enoxaparin?

What is a standard full anticoagulation dose of enoxaparin?

• A. 2 mg/kg SQ daily
• B. 1 mg/kg SQ BID
• C. 30 mg SQ daily
• D. 0.5 mg/kg SQ daily

Answer: (B)

Therapeutic dosing of enoxaparin is weight-based and given by subcutaneous injection. For acute coronary syndromes and other indications requiring full anticoagulation, the standard regimen is 1 mg/kg of body weight every 12 hours. This BID schedule provides a consistent therapeutic level to inhibit thrombin and factor Xa activity, helping prevent clot growth and new clots without proceeding to an unnecessarily higher dose. The other options are not standard for full therapeutic anticoagulation: 2 mg/kg once daily delivers more total daily anticoagulant effect than the usual regimens and isn’t routinely used; 30 mg daily is a prophylactic (not therapeutic) dose; 0.5 mg/kg daily is subtherapeutic for treatment.

Therapeutic dosing of enoxaparin is weight-based and given by subcutaneous injection. For acute coronary syndromes and other indications requiring full anticoagulation, the standard regimen is 1 mg/kg of body weight every 12 hours. This BID schedule provides a consistent therapeutic level to inhibit thrombin and factor Xa activity, helping prevent clot growth and new clots without proceeding to an unnecessarily higher dose.

The other options are not standard for full therapeutic anticoagulation: 2 mg/kg once daily delivers more total daily anticoagulant effect than the usual regimens and isn’t routinely used; 30 mg daily is a prophylactic (not therapeutic) dose; 0.5 mg/kg daily is subtherapeutic for treatment.