Tenecteplase dosing in STEMI is administered as which of the following?

Tenecteplase dosing in STEMI is administered as which of the following?

• A. Weight-based IV bolus
• B. Fixed dose for all patients
• C. Infusion over 60 minutes
• D. Not used in ACS

Answer: (A)

Tenecteplase is given in STEMI as a single intravenous bolus, with the dose chosen based on the patient’s body weight. This weight-based, single-bolus approach takes advantage of the drug’s longer half-life and greater fibrin specificity, allowing rapid reperfusion without the need for a prolonged infusion. Therefore, the correct practice is a weight-based IV bolus. It is not a fixed dose for all patients, and it is not administered as an infusion over 60 minutes. Tenecteplase is used in ACS when fibrinolysis is appropriate, rather than not used at all.

Tenecteplase is given in STEMI as a single intravenous bolus, with the dose chosen based on the patient’s body weight. This weight-based, single-bolus approach takes advantage of the drug’s longer half-life and greater fibrin specificity, allowing rapid reperfusion without the need for a prolonged infusion. Therefore, the correct practice is a weight-based IV bolus. It is not a fixed dose for all patients, and it is not administered as an infusion over 60 minutes. Tenecteplase is used in ACS when fibrinolysis is appropriate, rather than not used at all.